Polyglycan® Sterile Solution was originally developed to be used as a post-surgical lavage of synovial compartments with the intention of replacing synovial fluid lost during surgery. Polyglycan contains naturally occurring components of synovia that play a central role in maintaining the homeostatic environment of the joint.
Composition
Highly viscous aqueous solution of defined fractions of purified Hyaluronic acid, Chondroitin sulfates C4 & C6 in a 10% solution of N-acetyl-D-glucosamine.
Each 10 mL vial contains:
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Hyaluronic acid sodium salt: 50.0 mg
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Sodium chondroitin sulfate: 1000 mg
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N-acetyl-D-glucosamine: 1000 mg
Pharmacology
Glucosaminoglycans are important components of all extracellular tissue structures including cartilage and synovial fluid. The active components in Polyglycan exhibit viscoelastic and polyionic properties similar in nature to synovial fluid. Introducing Polyglycan into the synovial space as a post-surgical lavage and fluid replacement will assist in the normalization of the joint following arthrotomy.
Use as a SYSTEMIC ARTHROTHERAPY
Some clients consider POLYGLYCAN® to be a combination of Adequan and Legend. Although this is not exactly accurate, Polyglycan does contain components that are representative of both.
Soon after it's introduction into the equine market, off-label intraarticular and intravenous applications quickly popularized.
In our experience, Polyglycan has comparable benefit to Legend with respect to both intravenous and intraarticular administration. Some clients think that it works better than Legend when administered intravenously (IV), although this comprises the minority of opinions.
We do implement Polyglycan intraarticularly for post-surgical cases, although typically elect to use high-vicosity hyaluronan (i.e. Hylartin or Hivisc) as part of our intraarticular protocol in horses with chronic joint disease.
Some lay-people (not our clients) have complained of excessive hemorrhage/ bleeding as a result of Polyglycan administration, although these reports are highly-speculative and there have been no clinical observations to this effect.
For more information, please visit: http://www.arthrodynamic.com/polyglycan/index.php
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